Pharmaceutical Sciences

PHS 150 First Year Seminar (3 credits)

This first year Pharmaceutical Sciences seminar course will allow students to explore the history of medication and pharmacy (from "poisons" to drugs) and learn about pharmaceutical companies and rapid advances in the field. Through fun and engaging debates around ethical and social issues attached to a rapidly evolving field of biomedical research and healthcare, students will will engage and communicate effectively through written and oral modes of expression and learn to apply principles of cooperative and efficient teamwork while learning to develop academic success strategies to become successful scientist in the Pharmaceutical Industry and beyond. Students will also attend presentations by experts from pharmaceutical industries or biomedical professions and by our own program faculty on their research programs.

Attributes: First-Year Seminar, Undergraduate

PHS 151 Science Talk Seminar (0 credits)

This course is a seminar that engages students with faculty and experts in the field of Pharmaceutical Sciences by allowing the students to research the field of research of their faculty or scientist match and give a detailed presentation on the subject and person. The result will be seminar presentations driven by students and will introduce the importance of networking in the filed of Pharmaceutical Sciences which is build to advance quickly through these important communications amongst scientists.

Attributes: Undergraduate

PHS 203 Pharm Sciences Orientation II (1 credit)

"The course introduces students to the different steps in the new drug development process and familiarizes them with FDA regulations pertaining to each of these steps."

PHS 303 Pharma & Biopharmaceutics I (3 credits)

Provides the physicochemical and pharmaceutical principles for understanding the development, behavior, preparation, andstability of pharmaceutical dosage forms and drug delivery systems.

PHS 303L Pharmaceutics Laboratory (1 credit)

PHS 304 Intro Drug Discovery & Dev (3 credits)

This course will allow students to gain insight into the process of drug discovery and development. By interacting with different experts in the field of drug discovery and development, students will learn about the steps to drug discovery including new target identification, selection and validation, screening of potential candidates, us virtual reality technology (VR) to experience receptor-ligand interactions in 3 dimensional space, understanding the formulation process, packaging and delivery of new drugs and finally being exposed to to the important regulatory aspects of the drug discovery process and how it applies to taking novel discoveries to clinic and patients.

Attributes: Undergraduate

PHS 306 Research Techniques in PHS (3 credits)

The course will familiarize students with research techniques including chromatography, dissolution, electrophoresis,protein assays, and cell culture as it applies to the field of Pharmaceutical Sciences

Attributes: Undergraduate

PHS 309 Pharm-Biopharmaceutics II (3 credits)

Study of the fundamental principles of rate processes and their application to predicting and computing the rate of drugdissolution, absorption, distribution, metabolism, elimination, and pharmacological action.

Attributes: Undergraduate

PHS 317 Pharm-Biopharmaceutics II (4 credits)

Study of the fundamental principles of rate processes and their application to predicting and computing the rate of drugdissolution, absorption, distribution, metabolism, elimination, and pharmacological action.

Attributes: Undergraduate

PHS 391 Pharm Sciences Seminar I (1 credit)

PHS 400 Cosmetic Science (2 credits)

PHS 400L Cosmetics Laboratory (2 credits)

PHS 402 Controlled-Release Dosage Form (2 credits)

PHS 404 Pharm Sciences Seminar II (1 credit)

PHS 414 Advanced Pharma Analysis (1 credit)

This course explores in depth of all major analytical instruments utilized in Pharmaceutical Industry, especially those that can be utilized for specialized and precise characterization during drug discovery and development. This course will help prepare students to be trained on these instuments in the lab.

Attributes: Undergraduate

PHS 414L Advanced Pharma Analysis Lab (2 credits)

This course provides hands on training on all major analytical instruments in the laboratory utilized in pharmaceutical industry, especially those that provide specialized and precise characterization during drug discovery and development processes.

Attributes: Undergraduate

PHS 450 Manufacturing Pharmacy (2 credits)

PHS 450L Manufacturing Pharmacy Lab (1 credit)

PHS 495 Analysis of Current Literature (1-3 credits)

PHS 702 Controlled-Release Dosage Form (2 credits)

PHS 703 Pharma & Biopharmaceutics I (3 credits)

Provides the physicochemical and pharmaceutical principles for understanding the development, behavior, preparation, andstability of pharmaceutical dosage forms and drug delivery systems.

Restrictions: Enrollment is limited to Doctoral or Graduate level students.

PHS 703L Pharmaceutics Laboratory (1 credit)

PHS 704 Intro Drug Discovery & Dev (3 credits)

This course will allow students to gain insight into the process of drug discovery and development. By interacting with different experts in the field of drug discovery and development, students will learn about the steps to drug discovery including new target identification, selection and validation, screening of potential candidates, us virtual reality technology (VR) to experience receptor-ligand interactions in 3 dimensional space, understanding the formulation process, packaging and delivery of new drugs and finally being exposed to to the important regulatory aspects of the drug discovery process and how it applies to taking novel discoveries to clinic and patients.

Attributes: Doctoral

PHS 709 Pharm-Biopharmaceutics II (3 credits)

Study of the fundamental principles of rate processes and their application to predicting and computing the rate of drugdissolution, absorption, distribution, metabolism, elimination, and pharmacological action.

Attributes: Doctoral

PHS 714 Advanced Pharma Analysis (1 credit)

This course explores in depth of all major analytical instruments utilized in Pharmaceutical Industry, especially those that can be utilized for specialized and precise characterization during drug discovery and development in the Pharmaceutical Industry. This course is the pre-lab that will help prepare students to be trained on these instruments in the lab.

Restrictions: Enrollment is limited to Doctoral or Graduate level students.

Attributes: Doctoral

PHS 714L Advanced Pharma Analysis Lab (2 credits)

This course provides hands on training on all major analytical instruments in the laboratory utilized in pharmaceutical industry, especially those that provide specialized and precise characterization during drug discovery and development processes. This course is a lab.

Attributes: Doctoral

PHS 717 Pharm-Biopharmaceutics II (4 credits)

Study of the fundamental principles of rate processes and their application to predicting and computing the rate of drugdissolution, absorption, distribution, metabolism, elimination, and pharmacological action.

PHS 750 Advanced Pharmaceutics (4 credits)

PHS 751 Advanced Pharmaceutics (3 credits)

This course presents the areas of pharmaceutical sciences and drug delivery at an advanced level. The topics include physical properties of drugs, ionic equilibria, solubility and related phenomena, drug diffusion and permeability, drug stability, interfacial phenomena, colloids, micromeritics, drug dissolution, and biomaterials.

PHS 760 Reg Issues in Pharma (2 credits)

This course covers in depth the various steps in the process of filing drug approval applications.

Restrictions: Enrollment is limited to Graduate level students.

PHS 761 Pharmaceutical Product Dev (3 credits)

This course focuses on the process of drug development from laboratory to scale-up.

Prerequisites: PHS 703

Restrictions: Enrollment is limited to Doctoral or Graduate level students.

PHS 762 Pre-formulation and Phys Pharm (3 credits)

This is an introductory course in the study of pharmaceutical materials for their physico-chemical properties as they pertain to the development of formulations.

Prerequisites: PHS 703

PHS 763 Res Proj in Drug Dev & Ind Pha (3 credits)

An advanced level research project in a selected area of drug delivery systems.

Prerequisites: PHS 761

PHS 799 Master’s Research (1-10 credits)

PHS 811 Drug Diffusion and Controlled (2 credits)

PHS 813 Design of Experiments (2 credits)

PHS 851 Advanced Pharmaceutics (3 credits)

This course presents the areas of pharmaceutical sciences and drug delivery at an advanced level. The topics include physical properties of drugs, ionic equilibria, solubility and related phenomena, drug diffusion and permeability, drug stability, interfacial phenomena, colloids, micromeritics, drug dissolution, and biomaterials.

Attributes: Doctoral

PHS 860 Reg Issues in Pharma (2 credits)

This course covers in depth the various steps in the process of filing drug approval applications.

Restrictions: Enrollment is limited to Doctoral level students.

PHS 875 Drug Dynamics (3 credits)

PHS 880 Pharmaceutical Polymers (3 credits)

PHS 890 Pharmaceutics Seminar (1 credit)

PHS 895 Analysis of Current Literature (2 credits)

PHS 897 Research in Pharmaceutics (3 credits)

PHS 899 Doctoral Research (10 credits)

PHT 282 Pharmacology/Toxicology Orient (1 credit)

Introduction to research literature in pharmacology/toxicology.

PHT 305 Fundamentals of Pharmacology (3 credits)

Basic principles and therapeutic approaches to the treatment of diseases. Students will be introduced to the role and actions of drugs and their classes as they relate to biological receptors, disease, health, and body systems.

PHT 306 Biomethods in Pharmac & Tox (3 credits)

Survey of biological methods employed in pharmacology and toxicology to assess efficacy and safety of drugs and chemicals. Experiments are designed to illustrate pharmacological principles and to detect and evaluate potential local and systemic toxicities.

PHT 307 Introduction to Toxicology (2 credits)

"his course introduces the basic principles of the effects of toxic substances on biological systems, including consideration of the history, scope, and applications of toxicology, toxicant exposure, the mechanisms of toxic action, some major types of toxicants, and fundamental methods of toxicology studies. Students will apply the basic principles of toxicology to evaluate the safety risks in preclinical, environmental, and forensic studies and practices

PHT 320 Techniques in Pharmacol & Tox (2 credits)

A laboratory course designed to familiarize students with standard methodology used to assess drug and chemical safety.

Restrictions: Enrollment is limited to Undergraduate Day Division level students.

PHT 324 Pharmacology & Toxicology Sem (1 credit)

Presentation by students and discussion of primary scientific literature in pharmacology and toxicology by students and faculty.

PHT 340 Intro Neuropsychopharmacology (3 credits)

This course will provide a working knowledge of the neurobiological and neurochemical basis of behavior and the mechanism by which drugs influence synaptic neurotransmission to alter behavior and function in neurologic and psychiatric disorders.

Restrictions: Enrollment is limited to Undergraduate Day Division level students.

Attributes: Undergraduate

PHT 350 Toxicology of Drug Abuse (2 credits)

This course will consider the toxicity of deliberately ingested, inhaled, injected materials that are used to alter the psychological state. The course will provide a working knowledge of the neurobiological and neurochemical basis of behavior and the mechanism by which drugs influence synaptic neurotransmission to alter behavior and function in Addiction. No prior courses in pharmacology are required.

PHT 395 Research Experience (1-4 credits)

this course is a research opportunity for students to work with a faculty mentor (or faculty’s lab team members) to gain insight and skills in research literature interpretation, hypothesis testing, laboratory measures, and data analysis. The course is pass/fail, with specific objectives and expectations agreed upon by mentor and students, and can be taken multiple times.

PHT 403 Advanced Toxicology (3 credits)

This course introduces the biochemical, genetic, cellular basis of cytotoxicity. Based on this knowledge, the course will study the toxic effects and their underlying mechanisms in different organ systems (e.g., liver, kidney, lung, eye, immunity, endocrine, and reproductive system).

Restrictions: Enrollment is limited to Undergraduate Day Division level students.

Attributes: Undergraduate

PHT 404 Pharmacology&Toxicology Sem II (1 credit)

Formal science-based presentations by students using primary scientific literature.

PHT 407 Applied Toxicology (3 credits)

This course considers topics related to organ-specific pathology and applications of clinical toxicology. Applied topics will mostly focus on substance use disorders-related toxicity, which is impacting lives worldwide. This course focuses on the toxicity of deliberately ingested, inhaled, injected materials that are used to alter the psychological state. The course will provide a working knowledge of the neurobiological and neurochemical basis of behavior and the mechanism by which drugs influence synaptic neurotransmission to alter behavior and function in Addiction. The course will provide a working knowledge of toxicology principles that impact specific disease states and therapy. No prior courses in pharmacology are required.

Attributes: Undergraduate

PHT 421 Advanced Medicinal Chem/Pharm (4 credits)

This course will introduce concepts involved in drug actions in the body. Principles of medicinal chemistry, pharmacokinetics, pharmacodynamics and pharmacogenomics will be explored from a theoretical standpoint with integration of chemical and biological principles.

Restrictions: Enrollment is limited to Undergraduate Day Division level students.

Attributes: Undergraduate

PHT 440 Drug Disc Neurodegenerative (3 credits)

PHT 450 Analysis of Publications (1-3 credits)

The purpose of this course is to use the information learned from retracted scientific papers in the medical/pharmaceutical field to teach many aspects of scientific publication. The class will discuss the specific reasons for the retractions, for example, errors in data, plagiarism, or fraudulent data including manipulated photo images. Using data from subsequent publications that led to the particular retraction, we will analyze the original data in terms of the rigor of statistics, reproducibility, and hints of data manipulation. We will also analyze the impact of the retracted papers on the scientific concepts and to public health. A retracted paper means that the particular data no longer exist in the literature; therefore in this course, we will discuss the ethics and responsibility of authorship, including coauthors. We will also discuss the process of scientific publication and the peer review process that varies widely among journals. Examples of the adverse consequences of retracted papers to medical science, to the biomedical community, and to the public at large will be given in class and discussed in terms of the responsibility of scientists and the ethics in scientific publications. For students electing to receive a letter grade in the course, two written assignments will be required.

Attributes: Undergraduate

PHT 460 Toxicology of Drug Abuse (3 credits)

This course will consider the toxicity of deliberately ingested, inhaled, injected materials that are used to alter the psychological state.The course will provide a working knowledge of the neurobiological and neurochemical basis of behavior and the mechanism by which drugs influence synaptic neurotransmission to alter behavior and function in Addiction.

Attributes: Undergraduate

PHT 470 Special Topics Pharmacology (4 credits)

This course will describe pharmacological classes of therapeutic agents with emphasis on mechanisms of actions at the cellular and organ levels. Students will also participate in interactive learning related to special topics in pharmacology.

Attributes: Undergraduate

PHT 471 Special Topics in Toxicology (3 credits)

This course considers special topics related to organ-specific pathology and applications of clinical toxicology. Special topics may include substance use disorders, cancer therapeutics, immunotherapy, nanotherapy, and the toxicology of medical devices. The course will provide a working knowledge of toxicology principles that impact specific disease states and therapy.

PHT 495 Independent Research Project (1-4 credits)

"This course is a research opportunity for students to work with a faculty mentor (or faculty’s lab team members) to gain insight and skills in research literature interpretation, hypothesis testing, laboratory measures, and data analysis, as well as research summarization and conclusion generation, with poster preparation and data presentation to a broad audience. Faculty mentor and student should agree upon the specific objectives and expectations for the course at the beginning of the course; usually the course will follow one or more PC 395 courses, with the added course requirement here for preparation and presentation of data at a local or regional science meeting. This course can be taken multiple times."

PHT 703 Advanced Toxicology (3 credits)

This course introduces the biochemical, genetic, cellular basis of cytotoxicity. Based on this knowledge, the course will study the toxic effects and their underlying mechanisms in different organ systems (e.g., liver, kidney, lung, eye, immunity, endocrine, and reproductive system).

Restrictions: Enrollment is limited to Doctoral or Graduate level students.

PHT 707 Applied Toxicology (3 credits)

This course considers topics related to organ-specific pathology and applications of clinical toxicology. Applied topics will mostly focus on substance use disorders-related toxicity, which is impacting lives worldwide. This course focuses on the toxicity of deliberately ingested, inhaled, injected materials that are used to alter the psychological state. The course will provide a working knowledge of the neurobiological and neurochemical basis of behavior and the mechanism by which drugs influence synaptic neurotransmission to alter behavior and function in Addiction. The course will provide a working knowledge of toxicology principles that impact specific disease states and therapy.

Restrictions: Enrollment is limited to Graduate level students.

PHT 721 Advanced Medicinal Chem/Pharm (4 credits)

This course will introduce concepts involved in drug actions in the body. Principles of medicinal chemistry, pharmacokinetics, pharmacodynamics and pharmacogenomics will be explored from a theoretical standpoint with integration of chemical and biological principles.

Restrictions: Enrollment is limited to Graduate level students.

PHT 740 Drug Disc Neurodegenerative (3 credits)

The goal of this course is to examine the drug discovery process with focus on neurodegenerative disorders. Using Alzheimer’s disease for illustration, we will examine diagnosis, epidemiology, current therapeutics, strategies for drug discovery (amyloid hypothesis, tau, apo E, insulin, and various receptors) in vitro and in vivo disease models. We will examine the in vivo models to see how well they simulate the disease and thus how reliable they may be in translational studies. Although the focus of the course is on preclinical studies, we will examine how some of the compounds that have done well in preclinical studies have fared in clinical studies thus illustrating challenges in this field.

Restrictions: Enrollment is limited to Graduate level students.

PHT 750 Research Ethics and Conduct (3 credits)

"This course discusses research ethics and publication ethics and delves into data manipulations, including image manipulation, statistical manipulation such as p-hacking. The course uses retracted literature that are known to contain errors or manipulated data, and failed to be reproduced by other scientists. This course discusses the adverse consequences of retracted papers to medical science, to the biomedical community and to the public at large and focuses on the responsibility of scientists and the ethics in scientific publications as an author or co-author. The course is entirely online. There will be 5 modules of different topics. "

PHT 752 Intro Scientific Data Analysis (1 credit)

The course is designed to give an introduction to the important maxim of “truth” in science. The foundation of science is the data that form the basis of hypothesis must be verifiable. Errors in science do occur and can lead to retraction, that leads to the concept of science being a self- correcting process. In this introductory course, we use retracted literature (from both basic research and clinical research) to teach students how to analyze data. Retracted literature are known to be due to errors or manipulated data, many are highly cited papers and published in high impact journals. In this course we will discuss the source of errors, for example in image manipulation, interpretation of statistical p-value. We will also discuss the ethics in conducting research. As an introductory course, this course can be taken as a "stand alone" course as well as in conjunction with the existing PHT750 courses to satisfy students who need 3-credit electives.

Restrictions: Enrollment is limited to Doctoral level students.

PHT 770 Special Topics in Pharmacology (4 credits)

This course will describe pharmacological classes of therapeutic agents with emphasis on mechanisms of actions at the cellular and organ levels. Students will also participate in interactive learning related to special topics in pharmacology.

Restrictions: Enrollment is limited to Doctoral level students.

PHT 799 Master’s Research (1-10 credits)

"Candidates for the master of science degree complete an independent research project, equivalent to at least 10 research credits, under the direction of an Advisory Committee of graduate faculty."

PHT 801 Research Lit in Pharm/Tox (1 credit)

"Weekly presentations by graduate students and faculty on current research papers from journals relevant to the fields of pharmacology and toxicology, followed by group discussion. Attendance and active participation are required during fall and spring semesters."

PHT 807 Applied Toxicology (3 credits)

This course considers topics related to organ-specific pathology and applications of clinical toxicology. Applied topics will mostly focus on substance use disorders-related toxicity, which is impacting lives worldwide. This course focuses on the toxicity of deliberately ingested, inhaled, injected materials that are used to alter the psychological state. The course will provide a working knowledge of the neurobiological and neurochemical basis of behavior and the mechanism by which drugs influence synaptic neurotransmission to alter behavior and function in Addiction. The course will provide a working knowledge of toxicology principles that impact specific disease states and therapy.

Restrictions: Enrollment is limited to Doctoral level students.

PHT 810 Research in Pharm and Tox (3 credits)

PHT 811 Research Techniques Laboratory (1-3 credits)

"During the first year of enrollment, each student satisfactorily completes an experiential rotation through the research laboratories of at least two departmental graduate faculty and selects a primary research topic."

PHT 821 Molecular Pharmacology (3 credits)

"This is an advanced pharmacology course with a focus on cell signal transduction. Major mammalian signaling pathways will be reviewed and how therapeutics, especially anticancer therapeutics, perturb these signaling pathways for therapeutic purposes will be discussed. Instructors will provide appropriate recent review and research papers to the class. Students are required to read these papers and actively participate in class discussion. Students are also required to write a mock research proposal and present it in class."

PHT 840 Drug Disc Neurodegenerative (3 credits)

The goal of this course is to examine the drug discovery process with focus on neurodegenerative disorders. Using Alzheimer’s disease for illustration, we will examine diagnosis, epidemiology, current therapeutics, strategies for drug discovery (amyloid hypothesis, tau, apo E, insulin, and various receptors) in vitro and in vivo disease models. We will examine the in vivo models to see how well they simulate the disease and thus how reliable they may be in translational studies. Although the focus of the course is on preclinical studies, we will examine how some of the compounds that have done well in preclinical studies have fared in clinical studies thus illustrating challenges in this field.

Restrictions: Enrollment is limited to Doctoral level students.

Attributes: Doctoral

PHT 851 Drug Discovery & Development (3 credits)

"This is an advanced 3-credit course of pharmacology & toxicology focusing on drug discovery & development. The primary objective of this course is to provide students with an in-depth knowledge about the major steps involved in drug discovery and development with real examples. The course will cover all major stages for advancing a molecule from the pre-clinical space into clinical FIH (First in Human) trials. These include target identification and validation, screening and selection of appropriate targeting molecules, non-clinical safety assessment, PK/PD modeling, clinical trial design, FIH dose calculation and efficacy assessment, et al. In addition to the didactic teaching, students will be assigned with a group project to use the knowledge they have learned to solve problems in drug discovery and development. After completing the course, students will have a deep understanding and practical knowledge of how pharmaceutical industry develops small molecule chemicals and biological macromolecules to become life-saving medicines."

PHT 880 Pharm Tox Seminar (1 credit)

"Reports on current research topics by guest scientists, departmental faculty, and graduate students, followed by group discussion. Attendance and participation are required during fall and spring semesters."

PHT 899 Doctoral Research (10 credits)

"Candidates for the doctor of philosophy degree fulfill their thesis-directed research requirement, equivalent to at least 20 research credits, under the supervision of an Advisory Committee of graduate faculty."